Membranes Developed for Water Treatment, Drug Delivery

Researchers at the University of Illinois (UI) have developed a new generation of biomimetic membranes for water treatment and drug delivery.

The experimental membranes show significantly higher water transport than existing reverse-osmosis membranes used in water purification and desalination, the researchers said.

"We took a close look at how kidneys so efficiently transport water through a membrane with aquaporins, and then we found a way to duplicate that in a synthetic system," said Manish Kumar, a UI graduate research assistant and the paper's lead author.

Unlike most biological membranes, polymer membranes are very stable and can withstand considerable pressure, essential requirements for water purification and desalination processes. "Placing aquaporins in materials that we can use outside the body opens doors to industrial and municipal applications," Kumar said.

To make their protein-polymer membranes, the researchers begin with a polymer that self-assembles into hollow spheres called vesicles. While the polymer is assembling, the researchers add Aquaporin Z, a protein found in Escherichia coli bacteria.

"Aquaporin Z makes a hole in the membrane that only water can go through, so it's both fast and selective," said membrane specialist Mark Clark, a professor of civil and environmental engineering and one of the paper's co-authors.

"By varying the amount of Aquaporin Z, we can vary the membrane's permeability," Kumar said, "which could be very useful for drug-delivery applications."

With their high permeability and high selectivity, the biomimetic membranes also are ideal for water treatment by desalination. When tested, the productivity of the Aquaporin Z-incorporated polymer membranes was more than 10 times greater than other salt-rejecting polymeric membranes.

Currently, the experimental polymer membranes exist only as small vesicles. "Our next step is to convert the vesicles into larger, more practical membranes," Kumar said. "We also want to optimize the membranes for maximum permeability."

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