Review Links Dioxin to Increased Heart-related Mortality Rate

Dioxins, environmental pollutants resulting from the production and combustion of chlorinated compounds, have been linked to an increase in ischemic heart disease (IHD) and cardiovascular disease (CVD) mortality rates, as reported in a review article in the November 2008 issue of the peer-reviewed journal Environmental Health Perspectives (EHP).

A December 2007 PubMed search of English-language epidemiologic studies and their citations regarding dioxin exposure and CVD mortality provided the basis for the systemic review. The authors, researchers at the Harvard School of Public Health and the U.S. Environmental Protection Agency, selected studies on original mortality data from all cases of CVD or IHD. They excluded studies of leather, flavor, and fragrance workers, whose occupational exposures typically include not only dioxin but also cardiotoxic methylmercury, arsenic, and xylene. Finally, they grouped the studies by their quality, according to two well-recognized criteria. The studies considered to be of the highest quality found consistent and significant dose-related associations with IHD mortality and more modest associations with all-CVD mortality.

Although a number of epidemiologic studies have examined the association of dioxin exposure with CVD morbidity or mortality, the authors found no published systematic reviews on this topic. This is possibly because dioxin epidemiology research has focused primarily on the association with various cancers.

The authors wrote that future studies in both animals and humans should assess whether cardiovascular effects are present at environmentally relevant doses of dioxin.

To read the free article, visit http://www.ehponline.org/members/2008/11579/11579.html.

Download Center

  • Your Guide to Environmental Metrics that Drive Performance

    Translating sustainability into action starts with implementing the right metrics to assess your environmental risk and performance. Learn how to design metrics that improve your decision-making process and drive enterprise performance.

  • Unpacking ESG: 6 Questions You Were Too Afraid to Ask

    Environmental and Sustainability experts from Arcadis and Cority answer 6 of the most pressing questions EHS professionals have about getting started with Environmental, Social, and Governance (ESG) reporting.

  • 5 Keys to Best-in-Class Chemical Management

    Running a safe chemical program is challenging and complex: from knowing what's on-site to proper handling and disposal - all while navigating regulatory changes. Learn the best ways to mitigate chemical risk, get the most value out of your data, and gain buy-in for a chemical management solution.

  • Streamline Your Air Emissions Management

    See how consolidating all your emissions management functions into one centralized system can help you streamline your operations, more easily maintain compliance, and achieve greater time and cost savings.

  • A Crash Course in Creating the Right Environmental Scoring System

    Learn how to develop the right environmental scoring system so you can easily benchmark performance across all your facilities and gain a holistic view of your environmental programs.

  • Industry Safe