PNNL System Improves Toxic Metal Detection

The Department of Energy's Pacific Northwest National Laboratory (PNNL) in Richland, Wash., has developed a new rapid, portable and inexpensive detection system that identifies personal exposures to toxic lead and other dangerous heavy metals. The device can provide an accurate blood sample measurement from a simple finger prick, which is particularly important when sampling children.

PNNL's portable analyzer system accurately detects lead and other toxic metals in blood as well as in urine and saliva. Results are as reliable as those of current state-of-the-art mass spectrometry systems. This analyzer provides a quicker, simpler and easier method of monitoring toxic metal exposures in high-risk populations, such as industrial workers, children and people living in polluted areas.

A bit larger than a lunchbox, the new detection system is field-deployable with plug-and-play features that allow different sensors to be easily exchanged to detect a variety of heavy metal toxins. It is battery-operated and requires about 1.5 times the power of a typical laptop computer. The system also routinely delivers reliable measurements within a rapid two- to five-minute analysis period.

Early production cost estimates indicate that the device may be as much as 10 times less expensive than existing plasma mass spectrometry systems, which lack field portability and require samples to be returned to the lab for more analysis.

Recent attention to children's exposure to lead from toys and products from the Far East has heightened the interest in toxic exposures to heavy metals. The ability to quickly and accurately identify children with elevated blood lead levels is important in providing treatment to those who need it. In addition, large numbers of industrial workers may be routinely exposed to toxic heavy metals like cadmium, lead and mercury, which are known to induce various diseases.

"Our research has focused on optimizing the sensor systems to work with the biological complexities in blood, urine and saliva samples," said Wassana Yantasee, PNNL scientists and principal investigator. "Validation of these sensor platforms for use in biomonitoring is particularly important in developing a personalized exposure assessment strategy."

The device can use two classes of sensors for detecting lead and other heavy metals. The first is based on a flow injection system using a mercury-film electrode to analyze metals in blood, urine, or saliva samples.

To eliminate the use of toxic mercury in conducting the analysis, the second class of the sensor uses a mercury-free approach of nanostructure materials developed at PNNL. This involves use of either Self-Assembled Monolayers on Mesoporous Supports – SAMMS™ technology -- or functionalized magnetic nanoparticles that provide excellent detection sensitivity at a parts-per-billion level.

PNNL's research is supported by extramural grants from the Centers for Disease Control's National Institute of Occupational Safety and Health, and the National Institutes of Health's National Institute of Environmental Health Sciences.

Battelle, which operates PNNL for DOE, filed a patent application in December 2007 for the improved sensor technology used in this next-generation biomonitoring device. Battelle is seeking commercialization partners and welcomes companies interested in the technology to contact Bruce Harrer or access Portable Electrochemical Sensing System for more information.

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