Study: Ozone, Filters Linked to Sick Building Symptoms

A team of researchers at the U.S. Department of Energy's Lawrence Berkeley (Calif.) National Laboratory has found evidence that the prevalence of building-related symptoms increases with increasing outdoor concentrations of the pollutant ozone. They also have discovered that the type of air filter that some buildings use in their ventilation systems may also play a role in the prevalence of symptoms.

Building-related symptoms (BRS), more commonly known as sick building syndrome, are health symptoms reported by office workers that improve when they leave the workplace. The symptoms can include irritation of the eyes, nose, throat, respiratory tract, and skin, as well as headache and fatigue.

This is the first epidemiological evidence from a field study of a link between ambient ozone levels and BRS. It is also the first field evidence linking BRS to a specific filtration technology used in large buildings.

The study was conducted by Michael Apte, Ian Buchanan, Mark Mendell, and Anna Mirer of Berkeley Lab's Environmental Energy Technologies Division in collaboration with EPA, which collected the data.

Results originated from the team's analysis of data from an EPA study called BASE (Building Assessment Survey and Evaluation), in which 100 U.S. office buildings were studied for one week each in either the summer or winter between 1994 and 1998. That study included surveys of office workers and their self-reported health conditions, weather and workplace data, and environmental conditions in and around the buildings.

(No data on indoor or outdoor ozone levels was collected during the EPA's BASE study. Ozone data used in this analysis was obtained from the historical records of ambient air quality monitoring stations near the BASE buildings during the same time periods as the BASE buildings were studied.)

According to Apte, "Based on patterns of associations between building-related symptoms and certain volatile organic compounds indoors, we hypothesized that increasing levels of outdoor ozone would lead to higher prevalence of building-related symptoms among the occupants within a building."

Their analysis of the BASE data shows that the prevalence of upper respiratory symptoms in a building increases linearly with increasing concentration of outdoor ozone. It also shows that the indoor concentrations of formaldehyde, acetaldehyde, and organic acids including pentanal, hexanal and nonanal increased with increasing outdoor ozone. All of these are known sensory irritants, and formaldehyde is a known carcinogen.

In a second paper, the researchers report on how different types of building air filters can affect the prevalence of BRS symptoms. Data from a subset of buildings in the BASE study showed strong statistical connections between a certain type of air filter and increased BRS.

The team found that the combination of higher outdoor ozone levels and the use of a polyester or other synthetic filter correlates with a statistically significant increase in the prevalence of BRS compared to other types of air filters. This filter showed a significant association with lower and upper respiratory symptoms, cough, sore eyes, fatigue, and headache.

The research suggests that replacing the polyester/synthetic filter could have a major positive impact, reducing BRS prevalence by up to 75 percent in buildings with high outdoor ozone concentrations, and by up to 39 percent in lower ozone environments. "The study estimated that removing both risk factors -- higher ozone in outdoor air and polyester/synthetic filters -- could reduce BRS by 26 to 62 percent," says Apte.

Apte notes that the results of both studies require further verification. "This research is a first step, and it needs to be replicated in other studies with a statistical design specifically to address the ozone-symptom association and with accurate information on filters and ozone levels. The strongest studies would involve controlled interventions on these two factors," he says.

Two papers describing the results will be published in the journal Indoor Air. The work was funded by the Centers for Disease Control--National Institute for Occupational Safety and Health.

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