Environmental Protection

NC State, NIEHS Study Finds BPA Effects at Low Levels

New research from North Carolina State University and the National Institute of Environmental Health Sciences (NIEHS) shows significant reproductive health effects in rats that have been exposed to bisphenol-A (BPA) at levels equivalent to or below the dose that has been thought not to produce any adverse effects.

BPA is a chemical found in baby bottles, water bottles, canned foods, and an array of other consumer products. The potential health effects of BPA is currently the subject of intense debate.

The study found that female rats exposed to a BPA dose of 50 micrograms per kilogram of body weight (µg /kg) in their first four days of life experienced early onset of puberty. Female rats exposed to 50 milligrams per kilogram of body weight (mg/kg) during their first four days of life developed significant ovarian malformations and premature loss of their estrus cycle.

"The 50 mg/kg level is important," says lead researcher Heather Patisaul Ph.D.,, "because it is equivalent to the U.S. Environmental Protection Agency's 'Lowest Observable Adverse Effect Level' for BPA. So, by definition, we should not have seen significant effects at or below this level, but we did."

Patisaul, an assistant professor of biology at NC State, explains that the 50 µg /kg level is also significant because it is EPA's listed reference dose for BPA – meaning it is the level of BPA that EPA says a person can be exposed to on a daily basis without expecting any adverse effects after a lifetime of exposure.

Patisaul stresses that the research was done on rats, making it difficult to determine its applicability to humans but notes that "this adds to a growing body of evidence that exposure to low doses of BPA during development can impact female reproductive health."

The female rats in the study were exposed during the first four days of life because that is a sensitive developmental window for the rats, similar to a sensitive developmental stage that takes place for humans when they are still in the womb.

The study, "Neonatal bisphenol-A exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin releasing hormone neurons," was funded by NIEHS and published online June 17 by the journal Biology of Reproduction. The study was co-authored by Patisaul and Heather B. Adewale of NC State and Wendy N. Jefferson and Retha R. Newbold at NIEHS.

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