Study: Bad Air Can Raise Blood Pressure
Cardiovascular researchers at The Ohio State University Medical Center have reported a direct link between air pollution and its impact on high blood pressure, or hypertension.
"We now have even more compelling evidence of the strong relationship between air pollution and cardiovascular disease," said Dr. Sanjay Rajagopalan, section director of vascular medicine at Ohio State's Medical Center and co-author of the study.
Researchers exposed rats to levels of airborne pollutants that humans breathe everyday, noting the levels were still considerably below levels found in developing countries such as China and India, and in some parts of the United States. Short-term exposure to air pollution, over a 10-week period, elevates blood pressure in those already predisposed to the condition, the study shows. The results appear online and are scheduled for publication in an upcoming issue of Arteriosclerosis, Thrombosis, and Vascular Biology, a journal published by the American Heart Association.
"Recent observational studies in humans suggest that within hours to days following exposure, blood pressure increases," Rajagopalan says.
In a highly-controlled experiment, hypertensive rats were placed in chambers and exposed to either particulate matter or filtered air for six hours a day, five days a week, over a period of 10 weeks. At week nine, researchers infused angiotensin II, another pollutant, into mini-pumps within the chambers and monitored responses in blood pressure over one week.
The air pollution level inside the chamber containing particulate matter was comparable to levels a commuter may be exposed to in urban areas with heavy traffic such as downtown Manhattan. "Pre-exposure to air pollution markedly increased blood pressure responses following infusion of angiotensin II," added Rajagopalan.
"This study provides guidance for the EPA to change pre-existing stringent standards in the effort to reduce air pollution," says Rajagopalan. "Our study also confirmed a need for a broader based approach, from the entire world, to influence policy development."
Dr. Qinghua Sun, first author of the study, will analyze vascular function in humans before and after the summer Olympics in Beijing, China. With stringent laws to ensure good quality during the games, it is anticipated that the air quality will improve significantly in and around Beijing. "We expect to find a tangible impact on vascular function and blood pressure because ultimately the only thing that will have changed is levels of air pollution," says Sun.
Researchers at the University of Michigan, EPA, the Institute of Statistical Science and the New York University School of Medicine participated in the study.